For what it's worth, we added this to the Samtools/Htslib packages for manipulating DNA sequencing files: https://github.com/samtools/htslib/pull/581
The speed gains were very much worth it. We also fuzz tested with American Fuzzy Lop and found no issues. A big thumbs up from me.
The only thing I can see lacking, which sadly I didn't get around to fixing, is a proper "make install" target.